THE EFFECT OF MUTAGENS ON THE LEVEL OF CHROMOSOMAL ABERRATIONS IN BLOOD LYMPHOCYTES IN DESCENDANTS OF THE PARTICIPANTS OF THE ACCIDENT AT THE CHERNOBYL NUCLEAR POWER PLANT
Keywords:
chromosomes, aberrations, mutagenesis, descendants, Chernobyl disasterAbstract
According to the data of literature and the own research, the negative influence of triggering mutagens bleomycin and mitomycin C on the lymphocytes of blood in descendants of irradiated fathers has been found. The level of chromosomal disorders increased to 21.21% after the influence of bleomycin and to 17.77% – after the impact of mitomycin C. At bleomycin impact on blood lymphocytes of descendants of Chernobyl disaster liquidators, paired acentric fragments were significantly more often in comparison with the effect of mitomycin C.
References
Baleva LS, Sipyagina AE. Prediktory riska formirovaniya radiatsionno-indutsirovannykh stokhasticheskikh zabolevaniy v pokoleniyakh detey iz semey obluchennykh roditeley – aktual'naya problema sovremennosti. Rossijskij vestnik perinatologii i pediatrii. 2019;64(1):7-14. doi: 0.21508/1027-4065-2019-64-1-7-14. Russian
Glazko VI, Glazko TT. Istochniki protivorechiy v otsenke populyatsionno-geneticheskikh posledstviy Chernobyl'skoy avarii. Acta Naturae. 2013;5(1):48-64. Russian
Kovaleva OA. Tsitogeneticheskiye anomalii v somaticheskikh kletkakh mlekopitayushchikh. Czitologiya i genetika. 2008;(1):58-72. Russian
Nimker S, et al. Delineating the Effects of Ionizing Radiation on Erythropoietic Lineage-Implications for Radiation Biodosimetry. Health Physics. 2019;116(5):677-93. doi: 10.1097/HP.0000000000000975
Oradovskaya IV. 30 let tragedii v Chernobyle. Klinicheskiye i immunologicheskiye effekty u likvidatorov posledstviy avarii na Chernobyl'skoy atomnoy elektrostantsii. Osnovnyye itogi mnogoletnego monitoringa. Radiacionnaya biologiya. Radioe`kologiya. 2016;5(3):251-73. Russian
Soboleva OA, et al. Khromosomnyye aberratsii i polimorfizm genov reparatsii DNK u detey Kuzbassa, prozhivayushchikh v usloviyakh razlichnoy mutagennoy nagruzki. Politravma. 2013;5(6):56-60. Russian
Vasil`ev SA, Lebedev IN. Tsitogeneticheskiye i ekspressionnyye markery individual'noy radiochuvstvitel'nosti cheloveka. Medicinskaya genetika. 2018;17(1):3-8. Russian
Vereshchako GG, Khodosovskaya AM, Fedosenko OL. Radiatsionnoye porazheniye i puti vosstanovleniya reproduktivnoy sistemy samtsov mlekopitayushchikh. Minsk: Beloruskaya navuka; 2018. 175 p. Russian
Vorobczova IE, Semyonov AV. Kompleksnaya tsitogeneticheskaya kharakteristika lits, postradavshikh v rezul'tate avarii na Chernobyl'skoy AES. Radiacionnaya biologiya. Radioe`kologiya. 2006;46(2):140-51. Russian
Vy`soczkaya IV, et al. Aktual`ny`e voprosy` kancerogeneza. Klinicheskaya onkogematologiya. 2019;12(1):101-6. doi: 10.21320/2500-2139-2019-12-1-101-106. Russian
Downloads
Published
Issue
Section
License
Copyright (c) 2020 Н.В. Багацкая, В.И. Ковалёва
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
