EXTRA-ARTICULAR LESIONS AND IRREVERSIBLE CHANGES IN THE ORGANS AND SYSTEMS IN PATIENTS WITH JUVENILE ARTHRITIS

Abstract

To study the frequency and nature of changes in the organs and systems of children with juvenile arthritis (JIA), depending on the characteristics of the disease and its course (poly- and oligoarticular options) examined 96 patients. Violations of the cardiovascular system were recorded in 26,1 % of the study (with oligoarthritis - at 35,3 %, with arthritis – 22,9 %), kidney disease found 36,9 % of children with JIA (oligoarthritis when - at 45,5 %, and with arthritis - at 35,0 %). Changes in blood lipids were present in 56,3 % of children with JIA (oligoarthritis at – 58,3 % of the patients, with polyarthritis - in 55,9 % of patients) in the form of increased levels of total cholesterol and triglyceride lowering HDL. Index of comorbidity for children with JRA with the terms of the disease from 1 year to 3 years amounted to 2,43 ± 0,5 points, and more than 3 years - 3,31 ± 0,7 points. It found that the highest predictive value involvement in the pathological process of new organs and systems of patients with JIA are indicators of age at onset (r = - 0,3; p < 0,04), the number of affected joints (r = 0,3; p <0,05) and the activity of the process (r = 0,3; p <0,03).