Genetic associations of obstructive sleep apnoea syndrome in children with obesity
Keywords:
genetic associations, single nucleotide gene variants, obstructive sleep apnea syndrome, obesity, childrenAbstract
Observance of sleep hygiene together with rational nutrition and dosed physical activity contribute to the quality and duration of life. The aim of the study: to determine the contribution of single-nucleotide gene variants associated with the risk of obstructive sleep apnea syndrome in metabolically unhealthy obesity in children. Materials and methods. 52 obese children aged 14-18 years were examined by the method of complete genome sequencing (CeGat, Germany). Results. In the absence of SNV rs2307111 nucleotide substitution of the POC5 gene, the probability of developing obstructive sleep apnea syndrome in MUO increases 5 times (95% CI 1.22 - 20.48), p=0.025. Conclusions: TT SNV rs2307111 РОС5 is highly associated with the presence of MUO and OSAS in children
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