Association of single-nucleotide variants of the glucagon-like peptide-1 receptor gene with sweet taste preferences in children with obesity
DOI:
https://doi.org/10.53457/2023.1-2.8Keywords:
single nucleotide gene variants, sweet taste preferences, eating behavior, obesity, physiological body weightAbstract
Background. Single nucleotide variants (SNVs) of the glucagon-like peptide-1 receptor (GLP1R) gene determine impaired stimulation of anorexigenic neurons and inhibition of orexigenic neurons, which leads to a decrease in the feeling of satiety with an increase in the feeling of hunger and potential consumption of food. The aim of the study: to investigate the association level of SNVs of the GLP1R gene and sweet taste preference in the development of obesity among children. Materials and methods. 316 children aged 6-18 years were examined. The main group (n=252) was represented by children with obesity. The control group (n=64) consisted of children with physiological body weight. Randomly selected 52 obese children underwent whole genome sequencing (CeGat, Germany). Taste preferences were assessed for all children using the Food and Beverage Preference Questionnaire. Static analysis included variation and correlation analysis, method for assessing the spread of data (estimation of dispersion). The critical value of the level of statistical significance (p) for all types of analysis was accepted at the level of p<0.05 (5%). Results: The average level of sweet taste preference among obese children was 3.38±0.06 points, while in the control group it was 3.74±0.05 points, p=0.000013. 14 SNVs of the GLP1R gene were found among obese children: rs761386, rs1042044, rs1126476, rs2235868, rs3765468, rs61754624, rs6918287, rs6923761, rs10305420, rs1030542 1, rs10305457, rs10305492, rs10305493, rs1472308929. SNVs of the GLP1R gene were highly associated with obesity, respectively in ascending order: rs1126476 (40.4%), rs2235868 (42.3%), rs1042044 (42.3%), rs6918287 (55.8%). The highest correlation between sweet taste preference was observed for SNV rs6918287 (r=0.61, p<0.05), when comparing 14 SNVs of the GLP1R gene. Conclusions: In children with obesity, a violation of sweet taste preferences is noted, which is highly associated with the presence of SNV rs6918287 of the GLP1R gene.
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